Two-chain urokinase plasminogen activators for treatment of thro

Details Two-chain urokinase plasminogen activators for treatment of thro Two-chain urokinase plasminogen activators for treatment of thro

1988-01-14

1991-03-12

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435215, 435226, 435212, C12N 972, A61K 37547

Patent

active

049991949

ABSTRACT:
A fibrin specific two-chain plasminogen activator in a therapeutic dosage form. A method is also provided for dissolving clots in vivo by application to the body of a fibrin specific two-chain plasminogen activator in therapeutic dosage form.

REFERENCES:
patent: 4766075 (1988-08-01), Goeddel et al.
Ichinose et al., J. Biol Chem., vol. 261, pp. 3486-3489, 1986.
Van Zonneveld et al., Proc. Natl. Acad. Sci., vol. 83, pp. 4670-4674, 1986.
Holmes, W. et al, Bio./Technology, vol. 3, pp. 923-929, 1985.
Rijken et al., J. Biol. Chem., vol. 256, pp. 7035-7041, 1981.
Lijnen, et al., Eur. J. Biochem., vol. 169, pp. 359-364, 1987.
Lijnen, et al., J. Biol. Chem., vol. 261, pp. 1253-1258, 1986.

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