Tweak receptor

Details Tweak receptor Tweak receptor

2009-01-16

2010-06-08

Harris, Alana M. (Department: 1643)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S325000, C435S331000, C435S347000

Reexamination Certificate

active

07732588

ABSTRACT:
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.

REFERENCES:
patent: 2003/0105297 (2003-06-01), Rubben et al.
patent: WO 98/55508 (1998-12-01), None
patent: WO 99/61471 (1999-12-01), None
patent: WO 01/45730 (2001-06-01), None
patent: WO 02/22166 (2002-03-01), None
Nakayama M., et al. “Fibroblast growth factor—inducible 14 mediates multiple pathways of TWEAK-induced cell death,”J. Immunol170(1): 341-348, 2003.
Nakayama M., et al. “Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies,”Biocheml Biophys Resh Communis, 306: 819-825, 2003.
Wiley et al., “TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor,”Cytokine and Growth Factor Reviews, 14: 241-249, 2003.
PCT/US2005/037582 International Search Report, Mar. 2006.
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4).
Dermer (Bio/Technology, 1994, 12:320).

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