Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2009-01-16
2010-11-09
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S130100
Reexamination Certificate
active
07829675
ABSTRACT:
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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Nakayama M., et al. “Fibroblast growth factor—inducible 14 mediates multiple pathways of TWEAK-induced cell death,”J. Immunol170(1): 341-348, 2003.
Nakayama M., et al. “Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies,”Biocheml Biophys Resh Communis, 306: 819-825, 2003.
Wiley et al., “TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor,”Cytokine And Growth Factor Reviews, 14: 241-249, 2003.
PCT/US2005/037582 International Search Report.
Han et al. TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NK-kB through TNF receptor-associated factors. Biochem. Biophys. Res. Comm. 2003. vol. 305, pp. 789-796.
Fanslow, III William C.
Ketchem Randal R.
Kim Kristine M.
Wiley Steven R.
Helms Larry R.
Immunex Corporation
Machin Nathan A.
Natarajan Meera
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