Tungsten-188/carrier-free rhenium-188 perrhenic acid generator s

Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis

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534 10, 424 149, A61K 4300, C07F 1300

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active

052758028

ABSTRACT:
A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form.

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Ehrhardt et al "An Improved Tungsten-188/Rhenium-188 Generator for Radiotherapeutic Applications," Proc. of 34th Ann. Mtg. Society of Nucl. Medicine, Abs. #416 J. Nucl. Med. 28, 4, pp. 656.657 (1987).
A. P. Callahan et al "Availability of Rhenium-188 . . . from a Tungsten-188/Re-188 Generator for Therapeutic Applications," IBID, Abs. #417.
R. E. Lewis, "Production of 70-Day Tungsten-188 and Development of a 17 Hour Rhenium-188 Radioisotope Generator," J. Nucl. Med. pp. 804-805 (1966).
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