Tumour-specific animal proteins

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C514S002600, C530S300000, C530S350000

Reexamination Certificate

active

07811574

ABSTRACT:
CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal, breast, and lung cancers, autoimmune diseases, and related conditions.

REFERENCES:
patent: 6451320 (2002-09-01), Stephenne et al.
patent: 2005/0260634 (2005-11-01), Baldwin et al.
patent: WO9315763 (1993-08-01), None
patent: WO9514772 (1995-06-01), None
patent: WO0053748 (2000-09-01), None
patent: WO0157275 (2001-01-01), None
patent: WO0157276 (2001-01-01), None
patent: WO01/02828 (2001-11-01), None
Smith RT, 1994 (Clin Immunol, 41(4): 841-849).
White et al, 2001, Ann Rev Med, 52: 125-145.
Boon, 1992 (Adv Can Res, 58:177-210).
Kirkin et al, 1998 (APMIS, 106 : 665-679.
Gaiger, A et al, 2000 (Blood, 96(4): 1480-1489).
Ezzell (J. NIH Res, 1995, 7:46-49).
Spitler, 1995 (Cancer Biotherapy, 10:1-3).
Roitt et al, 1998, (Immunology, 4th ed, Mosby, London, p. 7.7-7.9).
Schmid S et al, 2001 (J comparative Neurology, 430(2): 160-71).
Conner et al, 1996 (Mol Brain Res, 42: 1-17).
Johnson et al, GenBank Accession No. S11562, in MPSRCH 2006 search report, us-10-650-608-25.rpr, pp. 1-3.
Roitt et al. 1998. Immunology, 4thed, Mosby, London, p. 5.6.
Bodey et al, 2000, Anticancer Res, 20: 2665-2676.
Mellman I, 2006, The Scientist, 20(1): 47-56.
Kaiser (Science, 2006, 313, 1370).
Database- Swiss-Prot Accession No. Q99929 (Nov. 1, 1997).
Database-EMBL Accession No. U77629 (Nov. 27, 1997).
Alders, et al., The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps To Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts, Human Molecular Genetics vol. 6, No. 6 pp. 859-867 (1997).
Database- Swiss-Prot Accession No. Q9WUJ7 (Nov. 1, 1999).
Database- Swiss-Prot Accession No. 035885 (Jan. 1, 1998).
Database- EMBL Accession No. U77628 (Nov. 27, 1997).
Database-EMBL Accession No. X53724 (Sep. 22, 1990).
Miyamoto, et al., “The Human ASCL2 Gene Escaping Genomc Imprinting and its Expression Pattern,” J. Assist. Reprod. Gene.
Westerman, et al., The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization. Placenta Jul. 2001;22(6):511-8.
Jiang, et al., Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2). Mol Endocrinol Oct. 2000; 14(10):1661-73.
Scott IC, et al., The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol Jan. 2000;20(2):530-41.
Tanaka, et al., Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev Sep. 1999;87(1-2):129-42.
Janatpour, et al., A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. J Dev Genet. 1999;25(2):146-57.
Kraut, et al., Requirement of the mouse I-mfa gene for placental development and skeletal patterning. EMBO J Nov. 2, 1998;17(21):6276-88.
Rossant, et al., Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev May 1998;73(2):183-91.
Miyamoto, et al., A SacII polymorphism in the human ASCL2 (HASH2) gene region. J Hum Genet 1998;43(1):69-70.
Hu, et al., A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. Genomics Nov. 15, 1997;46(1)9-17.
Tanaka, et al., Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol Oct. 1, 1997;190(1):55-65.
Nakayama, et al., Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev Genet 1997;21(1):21-30.
Miyamoto, et al., Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2). Cytogenet Cell Genet 1996;73(4):312-4.
Leighton, et al., An enhancer deletion affects both H19 and Igf2 expression, Genes Dev Sep. 1, 1995;9(17):2079-89.
Guillemot, et al., Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet Mar. 1995;9(3):235-42.
Guillemot, et al., Essential role of Mash-2 in extraembryonic development. AL. Nature Sep. 22, 1994;371(6495):333-6.
Johnson, et al., DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc Natl Acad Sci U S A Apr. 15, 1992;89(8):3596-600.
Johnson, et al., Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Development Jan. 1992;114(1):75-87.
Johnson, et al., Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature Aug. 30, 1990;346(6287):858-61.
mRNA-DNA GenBank Accession No. NM-005170.1.
mRNA-DNA GenBank Accession No. XM-113673.1.
mRNA-DNA GenBank Accession No. XM-113699.1.
mRNA-DNA GenBank Accession No. AF442769.1.
mRNA-DNA GenBank Accession No. S82817.1.
Protein GenPep Accession No. XP-113673.1
Protein GenPep Accession No. XP-113699.1.
Protein GenPep Accession No. AAL35362.1.
Protein GenPep Accession No. AAB39362.1.
Protein GenPep Accession No. NP—005161 (Journal: Hum. Mol. Genet. 6(6), 859-867 (1997)).
Protein GenPep Accession No. AAB39362.1, (Journal: Hum. Mol. Genet. 6(6), 859-867 (1997)).
Banerjea et al., Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity, Molecular Cancer 3:31 (2004).
Cui et al., Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability, Nature Medicine 4(11):1276 (1998).
Guillemot et al., Essential role ofMash-2in extraembryonic development, Nature 371:333 (1994).
Jiang et al., Hypoxia Prevents Induction of Aromatase Expression in Human Trophoblast Cells in Culture: Potential Inhibitory Role of Hypoxia-Inducible Transcription Factor Mash-2 (Mammalian Achaete-Scute Homologous Protein-2), Molecular Endrocrinology 14(10):1661 (2000).
Jiang and Mendelson, USF1 and USF2 Mediate Inhibition of Human Trophoblast Differentiation andCYP19Gene Expression by Mash-2 and Hypoxia, Moleculare and Cellular Biology, 23(17):6117 (2003).
Jiang and Mendelson, O2Enhancement of Human Trophoblast Differentiation andhCYP19(Aromatase) Gene Expression are Mediated by Proteasomal Degradation of USF1 and USF2, Molecular and Cellular Biology, 25(20): 8824 (2005).
Jubb et al., Achaete-scute like 2 (asc12) is a target of Wnt signaling and is upregulated in intestinal neoplasia, Oncogene 25:3445 (2006).
Koide et al., The Expression of Proprotein convertaase PACE4 Is Highly Regulated by Hash-2 in Placenta: Possible Role of Placenta-Specific Basic Helix-Loop-Helix Transcription Factor, Human Achaete-Scute Homologue-2, J. Biochem 134:433 (2003).
Massari and Murre, Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms, Molecular and Cellular Biology 20(2):429 (2000).
Miyamoto et al., The HumanASCL2Gene Escaping Genomic Imprinting and Its Expression Pattern, J. of Assisted Reproduction and Genetics, 19(5): 240 (2002).
Spink et al., Structural basis of the Axin-adenomatous polyposis coli interaction, The EMBO Journal 19(10):2270 (2000).
Westerman et al., The Human Achaete Scute Homolog 2 Gene Contains Two Promotors, Generating Overlapping Transcripts and Encoding Two Proteins with Different Nuclear Localization, Placenta 22:511 (2001).
Zhang et al., JMJD2A Is a Novel N-CoR-Interacting Protein and Is Involved in Repression of the Human Transcription Factor Achaete Scute-Like Homologue 2 (AS

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