Tumor treatment process and composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A61K 3120

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active

048958743

ABSTRACT:
Saturated aliphatic straight chain dicarboxylic acids having a total number of carbon atoms which are divisible by four, are selectively toxic to certain tumor cells while non-toxic to normal cells of the same origin. Octacosanedioic acid is particularly preferred as it is a component of normal blood serum. Compositions containing these compounds may be used in the treatment of certain malignancies.

REFERENCES:
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Boyland, E. "142. Experiments on the Chemotherapy of Cancer: 4. Further Experiments with Aldehydes and their Derivatives", Biochem J., 34:1196-1201 (1940).
F. C. Turner, "Experimental Chemotherapy of Tumors in Mice", Journal of the Nat. Cancer Inst., 4:265-270, (1943).
D. L. Woodhouse, "Chemotherapy Investigations in Cancer . . . ", Cancer Research 7:398-401 (1947).
Carter et al., Chemotherapy of Cancer, 2nd ed., John Wiley & Sons, N.Y., N.Y., 1981, pp. 361-365.
Dyer, An Index of Tumor Chemotherapy, Mar. 1949, pp. 10, 11 and 73, NIH (WO 2043).
Carter et al., Chemotherapy of Cancer, John Wiley & Sons, N.Y., N.Y., 1981, pp. 26-43.
Nazzaro-Porro, M. et al., "Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum", the Journal of Investigative Dermatology, 71:205-208 (1978).
Breathnach, A. S., et al., "Effect of Dicarboxylic Acids on Normal Human Melanocytes in Dispersed Tissue Culture", British Journal of Dermatology, 101, 641-649 (1979).
Nazzaro-Porro, M. et al., "Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum and their Melanocytotoxic Effect", Pigment Cell, vol. 4, pp. 234-243 (Karger, Basel 1979).
Nazzaro-Porro, M. et al., "Effect of Azelaic Acid on Human Malignant Melanoma", The Lancet, May 24, 1980, pp. 1109-1111.
Morgan, P., "Dicarboxylic Acids", Kirk-Othmer Encyclopedia of Chemical Technology, vol. 7, 3rd edition, pp. 614-628 1979, John Wiley & Sons.
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