Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1984-03-01
1990-01-23
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3120
Patent
active
048958743
ABSTRACT:
Saturated aliphatic straight chain dicarboxylic acids having a total number of carbon atoms which are divisible by four, are selectively toxic to certain tumor cells while non-toxic to normal cells of the same origin. Octacosanedioic acid is particularly preferred as it is a component of normal blood serum. Compositions containing these compounds may be used in the treatment of certain malignancies.
REFERENCES:
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Boyland, E. "142. Experiments on the Chemotherapy of Cancer: 4. Further Experiments with Aldehydes and their Derivatives", Biochem J., 34:1196-1201 (1940).
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Dyer, An Index of Tumor Chemotherapy, Mar. 1949, pp. 10, 11 and 73, NIH (WO 2043).
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Nazzaro-Porro, M. et al., "Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum", the Journal of Investigative Dermatology, 71:205-208 (1978).
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Rubin David
Rubin Ely J.
Century Laboratories, Inc.
Goldberg Jerome D.
Rubin David
Rubin Ely J.
Schwartz Irwin S.
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