Tumor therapy

Details Tumor therapy Tumor therapy

2007-08-21

2007-08-21

Harris, Alana M. (Department: 1643)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

C424S093100, C424S093200, C424S184100, C424S145100, C435S004000, C435S071100, C435S007210, C435S007230, C435S007920, C435S325000, C436S064000, C436S086000, C436S087000, C436S164000, C514S001000, C514S002600, C514S004300, C514S008100, C514S012200, C514S023000, C514S053000, C514S054000, C530S350000, C530S385000, C530S386000, C530S387100, C530S388100, C530S389100

Reissue Patent

active

11057105

ABSTRACT:
Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composition may be cells comprising expression constructs for the ligands, liposomes or combinations of protein molecules.

REFERENCES:
patent: 2004/0115198 (2004-06-01), Spies et al.
patent: WO98/19167 (1998-05-01), None
patent: WO 98/19167 (1998-05-01), None
patent: WO99/31241 (1999-06-01), None
patent: WO01/71005 (2001-09-01), None
Diefenbach et al. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature Immunology 1(2): 119-126, Aug. 2000.
Gura. Cancer Models: Systems for Identifying New Drugs Are Often Faulty. Science 278:1041-1042, 1997.
Diefenbach et al., Natural Killer Cells: Stress Out, Turn On, Tune In, Current Biology, Current Science, 9 (22), R851-R853 Nov. 18, 1999.
Pende et al., Role of NKG2D in Tumor Cell Lysis Mediated by Human NK Cells . . . , Nonepithelial Origin, Eur J Immunol 31 (4), 1076-1086 Apr. 2001.
Bauer et al., Activation of NK cells and T cells by NKG2D . . . , Science 285 (5428), 727-729, Jul. 30, 1999.
Diefenbach et al., Rae1 and H60 Ligands of the NKG2D receptor stimulate tumor immunity, Nature 413, 165-171, Sep. 13, 2001.
Diefenbach et al., Strategies for target cell recognition by natural killer cells, Immunol Reviews 181, 170-184, Jun. 2001.

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