Tumor tag and the use thereof

Details Tumor tag and the use thereof Tumor tag and the use thereof

2002-09-09

2009-02-03

Blanchard, David J. (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S320100, C435S325000, C435S069100, C530S350000, C530S388800, C536S023500

Reexamination Certificate

active

07485621

ABSTRACT:
The invention provides a new tumor tag, RL5 protein, the polynucleotide encoding RL5 protein, and the method of producing RL5 protein by recombinant technology. The invention also discloses the use of RL5 protein and the polynucleotides encoding RL5 protein, e.g., in diagnosing and treating tumor, as well as the pharmaceutical composition containing RL5 protein or the antibody against it.

REFERENCES:
patent: 2006/0134663 (2006-06-01), Harkin et al.
patent: WO 98/19167 (1998-05-01), None
Strausberg et al. (PNAS 99:16899-16903 (Dec. 2002)).
Protein sequence search alignments for SEQ Id No. 2 and amino acid residues 29-213 of SEQ Id No. 2 (pp. 1-2).
Sequence search alignment (pp. 1-3) Strausberg et al. (PNAS 99:16899-16903 (Dec. 2002).
Sequence search alignment (pp. 1-4) Bacon et al. (J. Immunol. 173:1078-1084 (2004).
McBride et al. (Clin. Chem 35(11):2196-2201 (1989).
Sequence alignment for SEQ Id No. 1 and SEQ Id No. 2 (Hood et al., U.S. Appl. No. 60/836,968, (filed Aug. 9, 2006)).
Sequence search for SEQ Id No. 1 (Trowsdale et al., U.S. Appl. No. 10/589,851, (filed Feb. 17, 2005)).
Sequence search for SEQ Id No. 1 (Harkin et al., U.S. Appl. No. 11/266,748, (filed Nov. 3, 2005)).
David Cosman et al.,ULBPs, Novel MHC Class I-Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxity through the NKG2D Receptor, Immunity, vol. 14, pp. 123-133, Feb. 2001.
Mirjana Radosavljevic et al.,A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2-q25.3, Genomics, vol. 79, No. 1, Jan. 2002, pp. 114-123.
Homo sapiens, UL16 binding protein 2, clone MGC:21383 Image: 4747126, mRNA complete cds., Aug. 16, 2002, BC034689, 1368 bp, mRNA linear.

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