Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-04-25
1996-07-02
Low, Christopher S. F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
930220, 536 235, 935 9, 935 29, C07K 1447
Patent
active
055323405
ABSTRACT:
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
Cobrinik et al., "Identification of a 126 kD E1A-Binding Protein That Forms G0/G1 Complexes with E2F," presented at Hood College, Fredrick Maryland, Ninth Annual Meeting on Oncogenes (Jun. 1992).
Hunkapiller et al. 1983 Methods Enzymol. 91:399-413.
Hannon et al. 1993 Genes & Dev. 7:2378-2391.
Robert A. Weinberg, "Tumor Suppressor Genes," Science, vol. 254, pp. 1138-1146 (Nov. 1991).
Giordano et al., "Human Cyclin A and the Retinoblastoma Protein Interact with Similar but Distinguishable Sequences in the Adenovirus E1A Gene Product," Oncogene 6, 481-485 (1991).
Ewen et al., "Molecular Cloning, Chromosomal Mapping, and Expression of the cDNA for p107, a Retinoblastoma Gene Product-Related Protein," Cell, vol. 66, pp. 1155-1164 (Sep. 1991).
Lee et al., "Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence" Science, vol. 235, pp. 1394-1399 (Mar. 1987).
Dyson et al., "Homogous Sequences in Adenovirus E1A And Human Papillomavirus E7 Proteins Mediate Interaction With the Same Set of Cellular Proteins", J. Virol., vol. 66, No. 12, pp. 6893-6902 (Dec. 1992).
Stratagene 1989 Product Catalog, pp. 34-37 (1989).
Mayol et al., "Cloning Of A New Member Of The Retinoblastoma Gene Family (pRB2) Which Binds To The E1A Transforming Domain", Oncogene, vol. 8, pp. 2561-2566 (Sep. 1993).
Li et al., "The Adenovirus E1A-Associated 130-kD Protein Is Encoded By A Member Of The Retinoblastoma Gene Family and Physically Interacts With Cyclins A And E", Genes and Development, vol. 7, pp. 2366-2377 (Dec. 1993).
Low Christopher S. F.
Temple University Of The Commonwealth System Of Higher Education
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