Tumor suppressor genes, proteins encoded thereby and use of said

Details Tumor suppressor genes, proteins encoded thereby and use of said Tumor suppressor genes, proteins encoded thereby and use of said

1996-04-12

1999-10-19

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 435 71, 435 6, 435325, 4351723, 436 63, 514 44, 536 231, 536 243, 536 241, C12N 1563

Patent

active

059688165

ABSTRACT:
The present invention describes the isolation and nucleic acid sequence of genes associated with cyptokine induced cell death. As long as these genes function normally, cytokines induce cell death; once the expression of these genes is inhibited, cytokine induced cell death is inhibited One aspect of the invention comprises expressing or the use of expression vectors to promote cell death in abnormal, pathological, cell growth such as cancer and psoriasis and another aspect of the invention is the protection of cells from programmed cell death in abnormal conditions such as Alzheimer's or Parkinson's disease. The invention can also be used as a screening device for predisportion to cancer or other uncontrolled cell growth diseases.

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