Tumor suppressor genes, proteins encoded thereby and use of said

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 235, 536 245, 4353201, C07H 2104, C12N 1512, C12N 1563

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active

061601063

ABSTRACT:
DNA molecules comprising a nucleic acid sequence expressed in cells, the expression product of which is involved in programmed cell death. Also disclosed are methods of therapeutic treatment using the DNA molecules and their expression products, and pharmaceutical compositions containing them.

REFERENCES:
patent: 4542096 (1985-09-01), Leder
patent: 4798787 (1989-01-01), McCormick et al.
patent: 5015570 (1991-05-01), Scangos et al.
patent: 5527676 (1996-06-01), Vogelstein et al.
patent: 5646008 (1997-07-01), Thompson et al.
L.P. Deiss et al., Identification of a novel serine/threonine kinase and a novel 15-kDa protein as potential mediators of the gamma-interferon-induced cell death EMBL Database Entry HSDAP1, Accession No. X76105, 1993, XP002102391.
Deiss et al., Genes Development, vol. 9, No. 1, 1995, pp. 15-30, XP002102392.
Baker et al., Suppression of Human Colorectal Carinoma Cell Growth by Wild-Type P53, Science, vol. 249, No. 4971, 1990, pp. 912-915, XP000293056.
Coetzer et al., Anti-Peptide antibodies to cathepsins B, L and D and type IV collegenase, Journal of Immunological Methods, vol. 136, 1991, pp. 199-200, XP002102393.
Kissel et al., Isolation of DAP3, mediator of IFN-gamma induced cell death, Journal of Biological Chenmistry, vol. 46, No. 270, 1995, pp. 27932, XP0020805782.
Feinstein et al., Assignment of DAP1 and DAPK-genes that positively mediate programmed cell death triggered by IFN-gamma-to chromosome regions 5p12.2 and 9q34.1, respectively. Genomics, vol. 29, 1995, pp. 305-307, XP002080573.
Tsujimoto, Y. et al.; Clustering of Breakpoints on Chromosome 11 in Human B-cell Neoplasms with the t(11;14) Chromosome Translocation; Nature, vol. 315; 340-343; 1985.
Lowe, S.W. et al.; P53 is Required for Radiation Induced Apoptosis in Mouse Thymocytes; Nature, vol. 362; 874-849; 1993.
Morin, P.J. et al.; Apoptosis and APC in Colorectal Tumorigenesis; Proc. Natl. Acad. Sci., vol. 93; 7950-7954, 1996.
Holmgren, L. et al.; Dormancy of Micrometasteses: Balanced Proliferation and Apostosi in the Presence of Angiogenesis Suppression; Nature Medicine, vol. 1, No. 2; 149-153, 1995.
Feinstein, E. et al.; The Death Domain: A Module Shared by Proteins with Diverse Cellular Functions; TIBS 20; 342-344, 1995.
Deiss, L.P. et al.; Identification of a Novel Serine/Threonine Kinase and a Novel 15-KD Protein as Potential Mediators of the .gamma. Interferon-Induced Cell Death; Genes & Development, 9:15-30, 1995.
Deiss, Louis P. et al. "A Genetic Tool Used to Identify . . . Signal" Sci., vol. 252, pp. 117-120 (1991).
Faust, Phyllis L. et al. "Cloning and Sequence . . . Cathepsin D" Proc. Natl. Acad. Sci. USA, vol. 82, pp. 4910-4914 (1985).
Owens, Gregory P. et al. "Identification of mRNAs . . . Thymocytes", Mol. & Cell. Bio., vol. 11, No. 8, pp. 4177-4188 (1991).
Wong, Paul et al. "Genomic Organization . . . Apoptosis" J. Bio. Chem., vol. 268, No. 7, pp. 5021-5031 (1993).
Nakano, Teruaki et al. "Transfection of Interferon-.gamma. . . . Death" Experimental Hematology, vol. 21, No. 11, pp. 1498-1503 (1993).
D'Mello, Santosh R. et al. "SGP2, Ubiquitin, 14K . . . Apoptosis" Molecular Neuroscience, vol. 4, No. 4, pp. 355-358 (1993).
Yonish-Rouach, Ellsheva et al. "Wild-type p53 Induces . . . Interleukin-6" Nature, vol. 352, pp. 345-347 (1991).
Itoh, Naoto et al. "A Novel Protein . . . Apoptosis" J. Bio. Chem., vol. 268, No. 15, pp. 10932-10937 (1993).
Moore, Jason et al. "Mutant H-RAS . . . Cells" Leukemia Report, vol. 1, No. 8, pp. 703-709 (1993).
Miura, Masayuki et al. "Induction of Apoptosis . . . Gene ced-3" Cell, vol. 75, pp. 653-660 (1993).
Abbadie, Corinne et al. "High Levels of c-rel . . . In Vitro" Cell, vol. 75, pp. 899-912 (1993).
Katre, Nandini V. et al. "Chemical Modification . . . Model" Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1487-1491 (1987).
Cavailles et al. (1993) Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells. Proc. Natl. Acad. Sci. USA 90:203-207, Jan. 1993.
Friedmann (1997) Overcoming the obstacles to gene therapy. Scientific American, Jun., pp. 96-101.
SIGMA Chemical Company Catalog (1990) p. 119.

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