Tumor suppressor gene, HIC-1

Details Tumor suppressor gene, HIC-1 Tumor suppressor gene, HIC-1

1998-05-26

2000-08-15

McKelvey, Terry

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303881, 5303888, C07K 1632

Patent

active

061038776

ABSTRACT:
Polynucleotide and polypeptide sequences encoding a novel tumor suppressor, HIC-1, are provided. Also included is a method for detecting a cell proliferative disorder associated with HIC-1. HIC-1 is a marker which can be used diagnostically, prognostically and therapeutically over the course of such disorders.

REFERENCES:
patent: 5618921 (1997-04-01), Burrell et al.
Liu et al, Developmental Biology, vol. 165, No. 1: pp. 165-177, Sep. 1, 1994.
Baylin, et al., Abnormal Patterns of DNA Methylation in Human Neoplasia: Potential Consequences of Tumor Progression, Cancer Cells, 3(10):383, 1991.
Kumagai, et al., Rapid, high-level expression of biologically active .alpha.-trichosanthin in transfected plants by an RNA viral vector, Proc. Natl. Acad. Sci. USA, 90:427, 1993.
Pieretti, et al., Hypermethylation at a Chromosome 17 "Hot Spot" Is a Common Event in Ovarian Cancer, Human Pathology, 26(4):398, 1995.
Wales, et al., p53 activates expression of HIC-1, a new candidate tumor suppressor gene on 17p13.3, Nature Medicine, 1(6):570, 1995.
Jones and Buckley, The Role of DNA Methylation in Cancer, Advances in Cancer Research, 54:1, 1990.

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