Tumor suppressor gene

Details Tumor suppressor gene Tumor suppressor gene

2006-12-26

2006-12-26

Yu, Misook (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C436S501000, C436S518000

Reexamination Certificate

active

07153935

ABSTRACT:
A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.

REFERENCES:
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Geck et al., “Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells:A new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus,”Journal of Steroid Biochemistry and Molecular Biology, Jan. 1999, 68 (1-2), pp. 41-50.
Nigro et al. “The human ROX gene: Genomic structure and mutation analysis in human breast tumors”,Genomics, 49(2), 1998, pp. 275-282.
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Wassenhove-McCarthy et al., “Molecular Characterization of a Novel Basement Membrane-associated Proteoglycan, Leprecan”, J. Biol. Chem., 274:25004-25017, 1999.
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Geck et al., “Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells:A new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus,”Journal of Steroid Biochemistry and Molecular Biology, Jan. 1999, 68 (1-2), pp. 41-50.
Nigro et al. “The human ROX gene: Genomic structure and mutation analysis in human breast tumors”,Genomics, 49(2), 1998, pp. 275-282.

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