Tumor suppressor gene

Details Tumor suppressor gene Tumor suppressor gene

1995-02-07

1996-09-24

Elliott, George C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 235, C12N 510, C07H 2104

Patent

active

055590233

ABSTRACT:
A detailed genetic map on human chromosome 11 was prepared. Then, a commonly deleted region on the chromosome in the tumor tissues of patients with multiple endocrine neoplasia type 1 was identified. Further, by linkage analysis of a family line with this disease, a genetic cause for this disease was localized. A gene present in the region common to these observations was cloned and the structure of this gene was determined. Because a protein coded by this DNA is homologous with those of transcriptional factors, it is expected that the above-mentioned gene may be a novel tumor suppressor gene. Further, it is also expected that the above-mentioned gene and a protein coded for thereby may be useful in preparation of a remedy for cancer and a diagnostic drug for cancer.

REFERENCES:
Toda et al., "Isolation and Characterization of a Novel Gene Encoding Nuclear Protein at a Locus (D11S636) Tightly Linked to Multiple Endocrine Neoplasia Type 1 (MEN1)", Human Molecular Genetics, vol. 3, No. 3, pp. 465-470. Mar. 94.
Tanigami et al., "A 14-Mb Physical Map of the Region at Chromosome 11q13 Harboring the MEN1 Locus and the Tumor Amplicon Region", Genomics, vol. 13, No. 1, pp. 16-20. 1992.
S. H. Friend et al, Proc. Natl. Acad. Sci. USA, Dec. 1987, vol. 84, pp. 9059-9063.
D. P. Lane et al, Nature, 15 Mar. 1979, vol. 278, pp. 261-263.
K. W. Kinzler et al, Science, 9 Aug. 1991, vol. 253, pp. 661-665.
K. M. Call, et al, Cell, 9 Feb. 1990, vol. 60, pp. 509-520.
D. Malkin et al, Science, 30 Nov. 1990, vol. 250, pp. 1233-1238.
S. Srivastava et al, Nature, 20/27 Dec. 1990, vol. 348, pp. 747-749.
M. L. Brandi et al, Endocrine Reviews, Nov. 1987, vol. 8, No. 4, pp. 391-405.
E. Takahashi et al, Human Genetics, 15 Nov. 1989, vol. 86, pp. 14-16.
Y. Nakamura et al, Am. J. Hum. Genet., 1988, vol. 43, pp. 854-859.
A. J. Buckler, et al, Proc. Natl. Acad. Sci., May 1991, vol. 88, pp. 4005-4009.
A. M. Maxam et al, Proc. Natl. Acad. Sci., Feb. 1977, vol. 74, No. 2, pp. 560-564.
J. Messing et al, Nucleic Acids Research, 1981, vol. 9, No. 2, pp. 309-321.
A. Hinnen et al, Proc. Natl. Acad. Sci., Apr. 1978, vol. 75, No. 4, pp. 1929-1933.
C. Gorman et al, Science, 5 Aug. 1983, vol. 221, pp. 551-553.
A. Becker et al, Proc. Nat. Acad. Sci., Feb. 1975, vol. 72, No. 2, pp. 581-585.
C. Cepko et al, Cell, Jul. 1984, vol. 37, pp. 1053-1062.
T. Sato et al, Cancer Research, 15 Nov. 1990, vol. 50, pp. 7184-7189.
D. Wu et al, Genomics, 1989, vol. 4, pp. 560-569.
G. Ruano et al, Nucleic Acids Research, 1989, vol. 17, No. 20, pp. 8392-8393.
C. R. Newton et al, Nucleic Acids Research, 1989, vol. 17, No. 7, pp. 2503-2517.
M. Orita et al, Proc. Natl. Acad. Sci., Apr. 1989, vol. 86, pp. 2766-2770.
M. Orita et al., Genomics, 1989, vol. 5, pp. 874-879.
C. Larsson et al, Nature, 3 Mar. 1988, vol. 332, pp. 85-87.
Y. Nakamura et al, Am. J. Hum. Genet., 1989, vol. 44, pp. 751-755.
T. Tokino et al, Am. J. Hum. Genet., 1991, vol. 48, pp. 258-268.
A. Tanigami et al, Am. J. Hum. Genet., 1992, vol. 50, pp. 56-64.
T. Hori et al, Genomics, 1992, vol. 13, pp. 129-133.
M. Fujimori et al, Am. J. Hum. Genet., 1992, vol. 50, pp. 399-403.
E. Friedman et al, New England Journal of Medicine, 1989, vol. 321, No. 4, pp. 213-218.
R. Thakker et al, New England Journal of Medicine, 1989, vol. 321, No. 4, pp. 218-224.
A. Bale et al, Cancer Research, 15 Feb. 1991, vol. 51, pp. 1154-1157.
C. Bystrom et al, Proc. Natl. Acad. Sci., Mar. 1990, vol. 87, pp. 1968-1972.
A. Tanigami et al, Genomics, 1992, vol., 13, pp. 21-24.
M. Gessler et al, Nature, 22 Feb. 1990, vol. 343, pp. 774-778.
U. Rosenberg et al, Nature, 23 Jan. 1986, vol. 319, pp. 336-339.
P. Chavrier, et al, The EMBO Journal, 1988, vol. 7, No. 1, pp. 29-35.
L. Joseph et al, Proc. Natl. Acad. Sci., Oct. 1988, vol. 85, pp. 7164-7168.
J. Arriza et al, Science, 1987, vol. 237, pp. 268-275.
A. Krust et al, The EMBO Journal, 1986, vol. 5, No. 5, pp. 891-897.
V. Giguere et al, Cell, 29 Aug. 1986, vol. 46, pp. 645-652.

Affiliated with

Also associated with

Rating

Tumor suppressor gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tumor suppressor gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor suppressor gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1928067