Tumor suppressor gene

Details Tumor suppressor gene Tumor suppressor gene

1996-04-19

1999-06-08

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 4351723, 4353201, 536 231, 536 235, C12N 1511, C12N 1509, C12N 510, C12N 1579

Patent

active

059104422

ABSTRACT:
The present invention relates to a novel tumor suppressor gene, SSeCKSS. It is based, at least in part, on the discovery of a gene, hitherto referred to as "322" (Lin et al., 1995, Mol. Cell. Biol. 15:2754-2762) but now referred to as SSeCKS, which was found to be down-regulated in certain transformed cells. Further, the SSeCKS gene product was subsequently shown to be a substrate of protein kinase C. SSeCKS protein has been shown to act as a mitogenic regulator and as an inhibitor of the transformed phenotype.

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