Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-05-15
2007-05-15
Huff, Sheela (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S380000, C530S385000, C530S387100, C530S388100, C530S388200, C530S388400, C424S134100, C424S141100, C424S135100, C424S009100, C435S188000, C435S009000
Reexamination Certificate
active
10299003
ABSTRACT:
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
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Jasser Samar A.
Pershouse Mark A.
Steck Peter
Tavtigian Sean V.
Yung Alfred W. K.
Baker Jonathan A.
Board of Regents The University of Texas Systems
Huff Sheela
Myriad Genetics Inc.
Myriad Genetics IP Dept.
LandOfFree
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