Tumor-specific promotor and use thereof

Details Tumor-specific promotor and use thereof Tumor-specific promotor and use thereof

2008-01-22

2008-01-22

Campell, Bruce R. (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000

Reexamination Certificate

active

10489258

ABSTRACT:
A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domain inserted in the E1 domain thereof exhibits a specifically high cell proliferation inhibitory effect on ovarian cancer cells. Thus, it is efficacious in gene therapy for ovarian cancer.

REFERENCES:
patent: WO 98/23779 (1998-06-01), None
Barker et al. Genomics 1996, vol. 38 (2), pp. 215-222.
David F. Barker, et al., “The BRCA1 and 1A1. 3B Promoters Are Parallel Elements of a Genomic Duplication at 17q21,” Genomics, Dec. 1996, pp. 215-222, vol. 38, No. 2.
Carla Heise, et al., “Replication-selective adenoviruses as oncolytic agents,” The Journal of Clinical Investigation , Apr. 2000, pp. 847-851, vol. 105, No. 7.

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