Tumor-specific promotor and use thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S320100, C435S325000

Reexamination Certificate

active

07321030

ABSTRACT:
A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domain inserted in the E1 domain thereof exhibits a specifically high cell proliferation inhibitory effect on ovarian cancer cells. Thus, it is efficacious in gene therapy for ovarian cancer.

REFERENCES:
patent: WO 98/23779 (1998-06-01), None
Barker et al. Genomics 1996, vol. 38 (2), pp. 215-222.
David F. Barker, et al., “The BRCA1 and 1A1. 3B Promoters Are Parallel Elements of a Genomic Duplication at 17q21,” Genomics, Dec. 1996, pp. 215-222, vol. 38, No. 2.
Carla Heise, et al., “Replication-selective adenoviruses as oncolytic agents,” The Journal of Clinical Investigation , Apr. 2000, pp. 847-851, vol. 105, No. 7.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tumor-specific promotor and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tumor-specific promotor and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor-specific promotor and use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2744749

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.