Tumor-specific genomic instability as a prognostic indicator

Details Tumor-specific genomic instability as a prognostic indicator Tumor-specific genomic instability as a prognostic indicator

1995-05-31

1996-11-26

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 935 77, 935 78, C12Q 168, C12P 1934

Patent

active

055784500

ABSTRACT:
A method for assessing the level of genomic instability in a malignant tumor is described. The method involves comparison of the structure of one or more interspersed repetitive sequence loci in tumor and corresponding normal tissue samples. Microsatellite repetitive sequences are one useful form of interspersed repetitive sequence that may be employed to characterize the genomic instability associated with some malignant tumors. This assessment provides an additional prognostic indicator for patients having such malignant tumors.

REFERENCES:
patent: 5075217 (1991-12-01), Weber
Perucho et al., Cell 27:467-476 (1981).
Bernues et al., Gene 108:269-274 (1991).
Dracopoli et al., Mapping the Human Amylase Gene Cluster on the Proximal Short Arm of Chromosome 1 Using a Highly Informative (CA)n Repeat, Genomics 7:97-102 (1990).
Nurnberg et al., DNA Fingerprinting With the Oligonucleotide Probe (CAC)5/(GTG)5: Somatic Stability and Germline Mutations, Hum. Genet. 84:75-78 (1989).
Tautz, Hpervariability of Simple Sequences as a General Source for Polymorphic DNA Markers, Nucleic Acids Res. 17:6463-71 (1989).
Weissenbach et al., A Second-Generation Linkage Map of the Human Genome, Nature 359:794-801 (1992).
Jeffreys et al., Individual-Specific Fingerprints of Human DNA, Nature 316:76-79 (1985).
Jeffreys et al., Minisatellite Repeat Coding as a Digital Approach to DNA Typing, Nature 354:204-209 (1991).
Lagoda et al., Increased Detectability of Somatic Changes in DNA from Human Tumours After Probing with "Synthetic" and Genome-Derived Hypervariable Multilocus Probes, Hum Genet., 84:35-40.
Kremer et al., Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence p(CCG)n, Science 252:1711-14 (1991).
Fu et al., Variation of the CGG Repeat at the Fragile X Site Results in Genetic Instability: Resolution of the Sherman Paradox, Cell 67:1047-58 (1991).
Hirst et al., Genotype Prediction in the Fragile X Syndrome. J. Med. Genet. 28:824-29 (1991).
La Spada et al., Androgen Receptor Gene Mutations in X-Linked Spinal and Bulbar Muscular Atrophy Nature 352:77-79 (1991).
Mahadevan et al., Myotonic Dystrophy Mutation: An Unstable CTG Repeat in the 3' Untraslated Region of the Gene, Science 255: 1253-55 (1992.
Brook et al., Molecular Basts of Myotonic Dystrophy: Extension of a Trinucleotide (CTG) Repeat at the 3' end of a Transcript Encoding a Protein Kinase Family Member, Cell 68:799-808 (1992).
Vogelstein et al., Genetic Alterations During Colorectal-Tumor Development, N. Engl. J. Med. 319:525-32 (1988).
Kern et al., Allelic Loss in Colorectal Carcinoma, J. Am. Med. Assoc. 261:3099-3103 (1989).
Offerhaus et al., The Relationship of DNA Aneuploidy to Molecular Genetic Alterations in Colorectal Carcinoma, Gastroenterology 102:1612-19 (1992).
Bufill et al., Colorectal Cancer: Evidence for Distinct Genetic Categories Based on Proximal or Distal Tumor Location, Ann. Int. Med. 113:779-88 (1990).
Ghahremani et al., Colorectal Carcinomas:Diagnostics Implications of their Changing Frequency and Anatomic Distribution, World J. Surg. 13:321-25 (1989).
DeLattre et al., Multiple Genetic Alterations in Distal and Proximal Colorectal Cancer, Lancet 2:353-56 (1989).
Rogers et al., Analysis of DNA in Fresh and Fixed Tissue by the Polymerase Chain Reaction, Am. J. Pottiol. 136:541-48 (1990).
J. L: Weber and P. E. May, Abundant Class of Human DNA Polymorphisms Which Can Be Typed Using the Polymerase Chain Reaction, Am. J. Hum. Genet. 44:388-96 (1989).
Y. Matsumura and D. Tarin, DNA Fingerprinting Survey of Various Human Tumors and Their Metastases, Cancer Res. 52:2174-2179 (1992).
M. F. Fey et al., Assessment of Clonality in Gastrointestinal Cancer by DNA Fingerprinting, J. Clin. Invest. 82:1532-37 (1988).
J. L. Weber, Informativeness of Human (dC-dA)n(dG-dT)n Polymorphisms, Genomics 7:524-30 (1990).

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