Tumor specific assay for CA125 ovarian cancer antigen

Details Tumor specific assay for CA125 ovarian cancer antigen Tumor specific assay for CA125 ovarian cancer antigen

1987-04-24

1990-05-01

Naff, David M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4351722, 435174, 435810, 436501, 436518, 436548, 436808, 436813, 530350, 530387, 530808, 530810, 935108, 935110, G01N 3353, G01N 33543, C07K 1514, C12N 100

Patent

active

049217909

ABSTRACT:
The present invention relates to a 40 kilodalton subunit of serous cystadinocarcinoma ovarian tumor associated antigen CA125, useful in the diagnosis and monitoring of ovarian cancer. It also relates to an immunoassay method for detection of the antigen in serum for diagnosis and monitoring purposes.

REFERENCES:
patent: 4584278 (1986-04-01), Knauf
patent: 4623621 (1986-11-01), Pestka
patent: 4666845 (1987-05-01), Mattes et al.
patent: 4713351 (1987-12-01), Knauf
Masuno et al., Cancer Research, vol. 44, Mar. 30, 1984, pp. 2813-2819.
Bast et al., The New England Journal of Medicine, vol. 309, No. 15, 1983, pp. 883-887.
Knauf and Urback, "A Study of Ovarian Cancer Patients using a Radioimmunoassay for Human Ovarian Tumor-Associated Antigen OCA," Am. J. Obstet. Gynecol., 138: 1222, 1980.

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