Tumor selective and biodegradable...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing

Reexamination Certificate

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C556S018000, C556S467000, C514S492000

Reexamination Certificate

active

08030506

ABSTRACT:
Disclosed are a novel cyclotriphosphazene-platinum(II) complex conjugate anticancer agent, showing high selectivity to tumor tissues due to the enhanced permeability and retention effect in tumor tissues and a preparation method thereof.

REFERENCES:
patent: 6221906 (2001-04-01), Sohn et al.
patent: 6333422 (2001-12-01), Sohn et al.
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Haag et al., “Polymer Therapeutics: Concepts and Applications”, Angew. Chem. Int. Ed., 45, 1198-1215 (2006).
Sohn et al., “Thermosensitive Cyclotriphosphazenes”, J. Am. Chem. Soc., 122, 8315 (2000).
Sohn et al., “Synthesis and Antitumor Activity of Novel Thermosensitive Platinum (II) Cyclotriphosphazene Conjugates”, J. Control. Release., 90, 303 (2003).
Sohn et al., “Thermoresponsive Micelles from Oligopeptide-Grafted Cyclotriphosphazenes”, Angew. Chem. Int. Edit., 45, 6173-6176 (2006).
Soyez et al., “The Crucial Role of Spacer Groups in Macromolecular Prodrug Design”, Adv. Drug Deliv. Rev., 21, 81-106 (1996).
Song et al., “Synthesis, Characterization, and Tumor Selectivity of a Polyphosphazene Platinum (II) Conjugate”, J. Control. Release., 105, 142-150 (2005).

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