Tumor retarding (1-benzyl-ethylenediamine)-platin (II)-complexes

Details Tumor retarding (1-benzyl-ethylenediamine)-platin (II)-complexes Tumor retarding (1-benzyl-ethylenediamine)-platin (II)-complexes

1986-02-21

1987-11-03

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

548109, 548402, 549 3, 549206, C07F 1500

Patent

active

047044640

ABSTRACT:
There are described (1-benzylethylenediamine)-platin(II)-complexes of the general formula: ##STR1## wherein the radicals R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different and are hydrogen, a C.sub.1 -C.sub.6 -alkyl group, a benzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R.sub.5, R.sub.6, an R.sub.7 which are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, phenoxy, benzyloxy, C.sub.1 -C.sub.6 -alkanoyloxy, benzoyloxy, C.sub.1 -C.sub.6 -alkanesulfonyloxy, carboxy, C.sub.1 -C.sub.6 -carbalkoxy, cyano, aminocarboxyl, aminocarbonyl, which contains one or two C.sub.1 -C.sub.6 -alkyl radicals, C.sub.1 -C.sub.6 -alkylcarbonyl, nitro, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, (C.sub.1 -C.sub.6 -alkyl).sub.3 N.sup.+, C.sub.1 -C.sub.6 -alkanoylamino, C.sub.1 -C.sub.6 -alkyl-C.sub.1 -C.sub.6 -alkanoylamino, C.sub.1 -C.sub.6 -alkanesulfonylamino, C.sub.1 -C.sub.6 -alkyl-C.sub.1 -C.sub.6 -alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C.sub.1 -C.sub.6 -alkyl radicals, C.sub.1 -C.sub.6 -alkoxysulfonyl (--SO.sub.2 --O--C.sub.1 --C.sub.6 -alkyl), sulfo (--SO.sub.3 H) or C.sub.1 -C.sub.6 -alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production.

REFERENCES:
patent: 4234500 (1980-11-01), Hoeschele et al.
patent: 4250189 (1981-02-01), Hydes et al.
patent: 4477387 (1984-10-01), Kidani et al.
patent: 4594418 (1986-06-01), Speer et al.
patent: 4598091 (1986-07-01), Schonenberger et al.
Chemical Abstracts 104 199664p (1986).
Hall et al., J. Inorganic Biochemistry 11, pp. 139-149 (1979).

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