Tumor necrosis factor receptors on microorganisms

Details Tumor necrosis factor receptors on microorganisms Tumor necrosis factor receptors on microorganisms

1992-01-23

1993-12-14

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 424 851, 4352521, 4352528, 435879, 435849, 435922, 4352554, A61K 3902, A61K 39112, A61K 39108, A61K 3900

Patent

active

052700380

ABSTRACT:
Cytokine receptors for tumor necrosis factor .alpha. which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries including vaccines with increased efficacy are provided.

REFERENCES:
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patent: 4820514 (1989-04-01), Cummins
patent: 5100664 (1992-04-01), Doyle et al.
Denis, M. et al., Interleukin-2 and Granulocyte-Marcophage Colony Stimulating Factor Stimulate Growth of a Virulent Strain of Escherichia coli, Infection and Immunity, 59(5): 1853-1856, 1991.
Le J. et al., Laboratory Investigation 56(3): 234-248, 1987.
Porat, R. et al., Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1, Science 254: 430-432, 1991.
Henney, C. S., Potential Therapeutical Applications of Interleukin-1, from a published transcript of the proceedings from the "International Conference on the Clinical Impact of Interleukins" at the Royal College of Physicians in London (Apr. 1989).

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