Tumor necrosis factor receptor-II-associated protein kinase and

Details Tumor necrosis factor receptor-II-associated protein kinase and Tumor necrosis factor receptor-II-associated protein kinase and

1996-01-18

1998-11-17

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 435194, C07K 14705

Patent

active

058378170

ABSTRACT:
The present invention provides an isolated and purified protein that associates with the cytoplasmic domain of the p80 form of the tumor necrosis factor receptor, having a molecular weight of 59 kDa on SDS-PAGE, is a phosphoprotein, and does not bind to the p60 form of the tumor necrosis factor receptor. Also provided is an isolated and purified protein kinase that associates with the cytoplasmic domain of the p80 form of the tumor necrosis factor receptor, said kinase phosphorylates both the p80 and p60 forms of the tumor necrosis factor receptor and phosphorylates a 59 kDa molecular weight protein associated with the cytoplasmic domain of the p80 form of the tumor necrosis factor receptor. Also provided are various methods of reducing the biological effects of tumor necrosis factor.

REFERENCES:
patent: 5563039 (1996-10-01), Goeddel et al
Rubin et al, Cancer Res 52, 1992, pp. 878-882.
Darnay et al, JBC 269, 1994, p. 20299.
Darnay et al JBC 269, 1994, p. 19687.
Song et al, Biochem J. 309, 1995, p. 825.
Ching et al Science 267, 1995 p. 1494.
Gaiddel et al J. Cell. Biochem , 18a, 1994, p. 5, (#1101).
Mosialas et al. Cell 80, p. 389, 1995.
Rothe et al. Cell 78, 1994, p. 681.
Tartaglia et al Cell 74, 1993, p. 845.
Song et al JBC 269, 1994, p. 22492.
Sato et al FEBS 358, 1995, p. 113.
Zhang et al J Immunol 153, 1994, p. 3749.

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