Tumor necrosis factor receptor-I-associated protein kinase and m

Details Tumor necrosis factor receptor-I-associated protein kinase and m Tumor necrosis factor receptor-I-associated protein kinase and m

1996-01-03

1999-01-05

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

530350, 530351, C07K 100

Patent

active

058561617

ABSTRACT:
The present invention provides an isolated and purified protein that associates with the cytoplasmic domain of the p60 form of the tumor necrosis factor receptor, having a molecular weight of about 52-55 kDa on SDS-PAGE, is a phosphoprotein, and does not bind to the p80 form of the tumor necrosis factor receptor. Also provided is an isolated and purified protein kinase that binds to the cytoplasmic domain of the p60 form of the tumor necrosis factor receptor, said kinase phosphorylates the p60 form of the tumor necrosis factor receptor. Also provided are various methods of manipulating this tumor necrosis factor receptor-associated protein and kinase in order to reduce various biological effects of tumor necrosis factor.

REFERENCES:
Rubin et al, Cancer Research 52, 1992, pp. 878-882.
Darnay et al JBC 269, 1994 p. 20299.
Darnay et al JBC 269, 1994 p. 19687.
Song et al., Biochem J. 309, 1995, p. 825.
Cheng et al Science 267, 1995, p. 1494.
Goeddell et al J. Cell Biochem 18A, 1994, p. 5, (#A011).
Mosialos et al Cell 80, 1995, p. 389.
Rothe et al Cell 78, 1994, p. 681.
Tartaglia et al, Cell 74, 1993, p. 845.
Song et al, JBC 269, 1994, p. 22492.
Sato et al, FEBS vol. 358, 1995, p. 113.
Zhang et al J. Immunol 153, 1994, p. 3749.

Affiliated with

Also associated with

Rating

Tumor necrosis factor receptor-I-associated protein kinase and m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tumor necrosis factor receptor-I-associated protein kinase and m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor necrosis factor receptor-I-associated protein kinase and m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-861438