Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1994-03-24
1997-01-28
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 695, 435 691, 530402, C07K 14525, C12P 2106
Patent
active
055978991
ABSTRACT:
Human TNF muteins having higher binding affinity for human p75-TNF receptor than for human p55-TNF receptor include muteins having at least one different amino acid relative to wild-type human TNF at a position corresponding to position 33, 65, 67, 75, 87, 143, 145 or 147 of the wild-type amino acid sequence.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4948875 (1990-08-01), Tanaka et al.
patent: 4990455 (1991-02-01), Yamagishi et al.
Yamagishi et al., "Mutational analysis of structure--activity relationships in human tumor necrosis factor-alpha", Protein Engineering 3:713-719 (1990).
Van Ostade et al., "Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis", EMBO J. 10:827-836 (1991).
Zhang et al., "Site-directed mutational analysis of human tumor necrosis factor-.alpha. receptor binding site and structure-functional relationship", J. Biol. Chem. 267:24069-24075 (1992).
Derwent Abstract Japanese Patent Appl. Publ. No. 03061495.
Fiers, "TNF: mechanisms of action in vitro and in vivo", in Influence of Molecular Biology on Drug Discovery ed. Udaka et al. (Munich, W. Zuckerschwerdt Verlag 1989) pp. 17-24.
Fiers, "Precursor structures and structure/function analysis of the TNF and lymphotoxin", in Tumor Necrosis Factors: Structure, Function and Mechanism of Action, ed. Aggarwal and Vilcek (Marcel Dekker, New York 1992), pp. 79-92.
Fiers, "In vitro and in vivo action of tumor necrosis factor", in Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy, ed. Bonavida and Granger, (S. Karger, Basel, 1990), pp. 77-81.
Fiers et al., "Lymphokines and monokines in anti-cancer therapy", in Cold Spring Harbor Symposium on Quantitative Biology, vol. LI (Cold Spring Harbor, 1986) pp. 587-595.
Mackay et al., "Tumor necrosis factor .alpha. (TNF-.alpha.)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55", J. Exp. Med. 177:1277-1286 (1993).
Loetscher et al., "Human tumor necrosis factor .alpha. (TNF.alpha.) mutants with exclusive specificity for the 55-kDa TNF receptors", J. Biol. Chem. 268:26350-26357 (1993).
Loetscher et al., "Activation of TNF receptors: structural and functional aspects", 8th Symposium Molecular Biology Hematopoiesis, Basel, Jul. 9-13, (Manuscript No. B 161 605).
Angehrn et al., "Two distinct tumor necrosis factor receptors in health and disease", in Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance, ed. Fiers & Buurman (Karger, Basle (1993)) pp. 33-39.
Warren et al., "The acute metabolic effects of tumor necrosis factor administration in humans", Arch Sur, 122:1396-1400 (1987).
Taguchi et al., "Clinical studies with TNF", Biotherapy 3:177-186 (1991).
Brouckaert et al., "In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-.gamma., on a syngeneic murine melanoma", Int. J. Cancer 38:763-769 (1986).
Van Ostade et al., "Human TNF mutants with selective activity on the p55 receptor", Nature 361:266-269 (1993).
Tartaglia and Goeddel, "Two TNF receptors", Immunology Today 13:151-153 (1992).
Barrett et al., "Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor", Eur. J. Immunol. 21:1649-1656 (1991).
Lewis et al., "Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific", Proc. Natl. Acad. Sci. USA 88:2830-2834 (1991).
Tsujimoto et al., "Comparative studies of the biological activities of human tumor necrosis factor and its derivatives", J. Biochem. 101:919-925 (1987).
Goh et al., "Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin)", Protein Eng. 4:785-791 (1991).
Carlino et al., "Use of a sensitive receptor binding assay to discriminate between full-length and truncated human recombinant tumor necrosis factor proteins", J. Biol. Chem. 262:958-961 (1987).
Tavernier et al., "Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: general properties and epitope analysis", J. Mol. Biol. 211:493-502 (1990).
Eck et al., "The structure of tumor necrosis factor-.alpha. at 2.6 A resolution", J. Biol. Chem. 264:17595-17605 (1989).
Yamagishi et al., Protein Eng. 3(4), 1990 p. 372 (abstract only).
Masegi et al., "Fundamental studies on novel recombinant tumor necrosis factor mutants", Protein Eng. 375-376 (1989).
Tsukio, "Novel physiologically active polypeptide", Patent Abstract of Japan, vol. 13, No. 119 (1989).
Lesslauer et al., "Cell-associated and soluble TNF receptors: perspective of new therapeutic strategies", in Maurice Rapin Colloquia Mediators of Sepsis: From Pathophysiology to Therapetic Approaches (Manuscript No. 161 230) (Paris, Flammarion 1993).
Cunningham et al., "Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis", Science 243:1330-1336 (1989).
Goh and Porter, "Structural and functional domains in human tumour necrosis factors", Protein Eng. 4:385-389 (1991).
Pennica et al, "Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin", Nature 312:724-729 (1984).
Banner David
Lesslauer Werner
Lotscher Hansruedi
Stuber Dietrich
Carlson Karen Cochrane
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Smith Catherine R.
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