Tumor necrosis factor-alpha mutants

Details Tumor necrosis factor-alpha mutants Tumor necrosis factor-alpha mutants

2011-08-09

2011-08-09

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C530S351000, C530S402000

Reexamination Certificate

active

07993636

ABSTRACT:
The present invention has an object to provide a tumor necrosis factor mutant protein, particularly, a tumor necrosis factor mutant protein specific to TNF-R1 or TNF-R2; tumor necrosis factor inhibitor; or tumor necrosis factor preparation containing it as an effective ingredient, and the object is solved by providing a tumor necrosis factor mutant protein where one or more amino acid residues selected from the group consisting of 29th, 31st, 32nd, 145th, 146th and 147th, or the group consisting of 84th to 89th from the N-terminal of the amino acid sequence of SEQ ID NO:1 is/are replaced with other amino acid residue(s); a tumor necrosis factor inhibitor; and a tumor necrosis factor preparation containing it as an effective ingredient.

REFERENCES:
patent: 5422104 (1995-06-01), Fiers et al.
patent: 5486463 (1996-01-01), Lesslauer et al.
patent: 0247860 (1987-12-01), None
patent: 0486908 (1992-05-01), None
patent: 0563714 (1993-10-01), None
patent: 1354893 (2003-10-01), None
patent: 62-289522 (1987-12-01), None
patent: 6-256395 (1994-09-01), None
patent: 7-285997 (1995-10-01), None
Zhang et al., Site-directed mutational analysis of human tumor necrosis factor-alpha receptor binding site and structure-functional relationship.
Van Ostade et al., Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis,The EMBO Journal, 10(4)827-836 (1991).
Zhang et al., Site-directed mutational analysis of human tumor necrosis factor-α receptor binding site and structure-functional relationship,The Journal of Biological Chemistry, 267(33)24069-24075 (1992).
Loetscher et al., Human tumor necrosis factor α (TNFα) mutants with exclusive specificity for the 55-kDa or 75 kDa TNF receptors,The Journal of Biological Chemistry, 268(35)26350-26357 (1993).

Affiliated with

Also associated with

Rating

Tumor necrosis factor-alpha mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tumor necrosis factor-alpha mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor necrosis factor-alpha mutants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2703403