Tumor-inhibiting protein and the use thereof

Details Tumor-inhibiting protein and the use thereof Tumor-inhibiting protein and the use thereof

2008-07-10

2011-10-04

Yu, Misook (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100

Reexamination Certificate

active

08030015

ABSTRACT:
The invention has disclosed a new tumor suppressor protein HCRP1, the polynucleotide sequences encoding this polypeptides, and methods for production of the polypeptide using the recombinant technology. The tumor suppression protein, HCRP1, is obtained through the positional candidate cloning strategy. It locates in 8p22 region of human chromosome. The full length cDNA for HCRP1 is 1916 bp, which encodes a protein of 397 amino acids. When introduced into liver cancer cells, HCRP1 can inhibit the malignant transformation of liver cancer cells.

REFERENCES:
patent: WO 0153312 (2001-07-01), None
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Bult et al (QJNMMI, 53:325-335, 2009).
Tockman et al (Cancer Res, 52:2711s-2718s, 1992).
Xu et al (Biochem. Biophys. Res. Comm., 311:1057-1066, 2003).

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