Tumor-inhibiting platinum (II) oxalate complexes

Details Tumor-inhibiting platinum (II) oxalate complexes Tumor-inhibiting platinum (II) oxalate complexes

2006-06-06

2006-06-06

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C514S492000

Reexamination Certificate

active

07057059

ABSTRACT:
A tumor-inhibiting platinum (II) oxalate complex and its use as a therapeutic agent are provided, in particular as a tumor-inhibiting medicament. The complex may be compounds of the general formula (I),wherein the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl and unsubstituted or substituted alkylaryl radicals, the substituents R5, R5′, R6, and R6′are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, and unsubstituted or substituted alkenyl radicals, and wherein optionally in each case at least two of the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′can form with one another at least one unsubstituted or substituted alkylene, unsubstituted or substituted alkenylene radical or an unsubstituted or substituted aromatic ring, and wherein optionally at least one of the carbon atoms of the cyclohexane ring bearing the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′is replaced by a heteroatom, and if the heteroatom is oxygen, the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′can additionally be hydroxy radicals, and pharmaceutically compatible salts of them, provided that at least one of the substituents R1, R1′, R2, R2′, R3, R3′, R4, or R4′is not equal to hydrogen and the substituents R1or R1′and R4or R4′do not form any unsubstituted C1-2-alkylene radical with one another.

REFERENCES:
patent: 4291027 (1981-09-01), Hoeschel et al.
patent: 4359425 (1982-11-01), Totani et al.
patent: 4670458 (1987-06-01), Hlavka et al.
patent: 4716157 (1987-12-01), Bitha et al.
patent: 0 310 260 (1989-04-01), None
patent: 0 464 210 (1992-01-01), None
patent: 0 646 589 (1995-04-01), None
patent: 0 801 070 (1997-10-01), None
patent: 61-037794 (1986-02-01), None
Galanski et al., European Journal of Medicinal Chemistry, vol. 39, No. 8, pp. 707-714 (2004).

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