Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-11-04
1990-04-17
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530806, 530808, 530828, 530395, 4351722, 43524027, 424 858, A61K 39395, C07K 1504, C12N 501
Patent
active
049181645
ABSTRACT:
The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T lymphocyte or on an immune suppressor factor which is directed against a defined tumor antigen, can be used for immunization against a tumor, for immune anti-tumor activation or inhibition of suppression, or for in vitro activation of lymphocytes to be used in adoptive immunotherapy. The anti-idiotypic antibodies, or fragments thereof, can also be used to monitor anti-antibody induction in patients undergoing passive immunization to a tumor antigen by administration of anti-tumor antibody. In another embodiment, administration of T lymphocytes which express an idiotype directed against a defined tumor antigen can be used to transfer delayed-type hypersensitivity to the tumor. In another method of the invention, the induction of anti-idiotypic antibodies in vivo by administration of anti-tumor antibody or immune cells or factors exhibiting an anti-tumor idiotype can be therapeutically valuable.
REFERENCES:
Nepom et al., PNAS(USA), 81, 2864-2867, (May 1984).
Brown et al., J. Immunol., 127(2), 539-546, (Aug. 1981).
Hellstrom Ingegerd
Hellstrom Karl E.
Kahn Maria S.
Kushan Jeff
Moskowitz Margaret
Oncogen
LandOfFree
Tumor immunotherapy using anti-idiotypic antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tumor immunotherapy using anti-idiotypic antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor immunotherapy using anti-idiotypic antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1053720