Tumor enzyme detection

Drug – bio-affecting and body treating compositions – Lymphokine

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424101, 436547, A61K 3900

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active

044420889

ABSTRACT:
A monospecific antibody prepared in response to cathepsin B proteinase by homogenizing purified cathepsin B proteinase upon dialyzing to remove ampholines, injecting a proteinase emulsion intramuscularly into an animal, reinjecting the animal with the proteinase emulsion, with drawing blood of the animal after sufficient time elapse for antibody production and isolating the monospecific antiserum from the blood.

REFERENCES:
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Chemical Abstracts, vol. 89, p. 441, Abst. No. 144790t, 1978.
Mort et al., The Journal of Histochemistry and Cytochemistry, vol. 29, pp. 649-657, 1981.
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Poole et al., Nature, vol. 273, pp. 545-547, 1978.
Recklies et al., Cancer Research, vol. 40, pp. 550-556, 1980.
Mort et al., Biochimica et Biophysica Acta, vol. 614, pp. 134-143, 1980.
Poole et al., Proteinases and Tumor Invasion, pp. 81-95, 1980.
Bansal et al., Acta Diabet. Lat., vol. 17, pp. 255-266, 1980.
Pierart-Gallois et al., Acta Biol. Med. Germ., vol. 36, pp. 1887-1891, 1977.
Sylven et al., Histochemistry, vol. 38, p. 35, 1974.
Sylven et al., Virch, Arch. B. Cell Pathol, vol. 17, p. 97, 1974.

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