Tumor environment-induced ligand-expressing nanocarrier system

Details Tumor environment-induced ligand-expressing nanocarrier system Tumor environment-induced ligand-expressing nanocarrier system

2008-05-13

2008-05-13

Woodward, Michael P. (Department: 1615)

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Aftertreated solid synthetic organic polymer

C424S400000, C514S772000

Reexamination Certificate

active

07371781

ABSTRACT:
Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

REFERENCES:
patent: 5543158 (1996-08-01), Gref et al.
Huh et al., Polymer 40 (1999) 6147-6155.
Salem et al, Advanced Materials 15 (2003) 210-213.
Gref et al., Biomaterials 23 (2003) 4529-4537.
Eun Seong Lee et al., Polymeric micelle for tumor pH and folate-mediated targeting, Journal of Controlled Release, 2003, pp. 103-113, vol. 91.
Eun Seong Lee et al., Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization, Journal of Controlled Release, 2003, pp. 363-374, vol. 90.
Kun Na et al., Self-Assembled Hydrogel Nanoparticles Responsive to Tumor Extra Cellular pH from Pullulan Derivative/Sulfonamide Conjugate: Characterization, Aggregation, and Adriamycin Release in Vitro, Pharmaceutical Research, May 2002, pp. 681-688, vol. 19, No. 5.
Kun Na et al., Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internaland cytoxicity in vitro, Journal of Controlled Release, 2003, pp. 3-13, vol. 87.
Kun Na et al., pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate, Journal of Controlled Release, 2004, pp. 513-525, vol. 97.

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