Tumor egress factor and processes for producing the same

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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530350, 530351, 530380, 530395, 530413, 530414, 530415, 530416, 530417, C07K 1506, C07K 328

Patent

active

050397940

ABSTRACT:
A novel cell scattering factor, i.e., tumor egress factor (hereinafter "egressin") isolated from a clone derived from a human metastatic melanoma (M3827) which possesses a loose colony morphology and from a human monocytic cell line (U937) and processes for producing the same. Egressin is useful for the production of immunological reagents for the detection and treatment of metastatic lesions, for aiding in the transport of drugs across the blood-brain barrier, and for aiding in the control of the inflammatory response.

REFERENCES:
Alitalo et al., EMBO J., 6(5), 1213-18, (1987).
DeLarco et al., PNAS (U.S.A.), 82, 5015-19, (Aug. 1985).
Liotta et al., PNAS (U.S.A.), 83, 3302-6, (May 1986).

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