Tumor derived carbohydrate binding protein

Details Tumor derived carbohydrate binding protein Tumor derived carbohydrate binding protein

1995-10-06

1997-10-28

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C07K 1447

Patent

active

056819234

ABSTRACT:
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced (SEQ. ID. NO:1). The polypeptide comprising the active site may be used as an immunotherapeutic agent. Identification of the site makes possible an in vivo diagnostic assay for metastatic cells as well as therapeutic methodologies and materials.

REFERENCES:
patent: 5260434 (1993-11-01), Liu
Raz, Cancer Research 51:2173-2178, 1991.
Oda, Gene 99:279-283, 1991.
Robertson, Biochemistry 29:8093-8100, 1990.
"Low Colony Formation I Vivo and in Culture as Exhibited by Metastatic Malanoma Cells Selected for reduced Homotypic Aggregation", Cancer Research 43:12088-2093, Lotan et al. (1983).
"A Lectin-Binding Protease-Resistant Mycobacteria Ligand Specifically Activates V.gamma.9+ Human .gamma..delta. T Cells", The Journal of Immunology, 148:575, Pfeffer et al. (1992).

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