Tumor cytotoxicity induced by modulators of the CXCR4 receptor

Details Tumor cytotoxicity induced by modulators of the CXCR4 receptor Tumor cytotoxicity induced by modulators of the CXCR4 receptor

2007-12-25

2007-12-25

Rawlings, Stephen L. (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C514S015800

Reexamination Certificate

active

10392324

ABSTRACT:
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.

REFERENCES:
patent: 5221610 (1993-06-01), Montagnier et al.

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