Tumor cytotoxicity induced by modulators of the CXCR4 receptor

Details Tumor cytotoxicity induced by modulators of the CXCR4 receptor Tumor cytotoxicity induced by modulators of the CXCR4 receptor

2011-06-14

2011-06-14

Harris, Alana M (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S001000, C514S001100, C514S019200, C514S019300, C514S019400, C514S019500, C514S021600

Reexamination Certificate

active

07960346

ABSTRACT:
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.

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