Tumor cytostatic-citocidal factor from blood platelets

Details Tumor cytostatic-citocidal factor from blood platelets Tumor cytostatic-citocidal factor from blood platelets

1986-03-21

1987-06-30

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 2, A61K 3514

Patent

active

046769838

ABSTRACT:
A tumor cytostatic-cytocidal factor is produced by disrupting platelets, extracting the disrupted platelets with an acidic aqueous solution or an acidic water-organic solvent mixture, and, after gel filtration, if desired, to separate a fraction having an estimated molecular weight of 10,000 to 20,000 and having tumor cell growth inhibiting activity, subjecting said extract or said fraction to chromatography to isolate a cytostatic fraction having a molecular weight of 10,000 to 20,000 and an isoelectric point of 9.0 to 10.0, giving a positive nihidrin reaction and being such that it is deactivated by trypsin but not deactivated by heating in physiological saline solution at 60.degree. C. for 30 minutes or contacting at room temperature with 0.2N hydrochloric acid for 60 minutes or 70% formic acid for 30 minutes.

REFERENCES:
Hara et al.-Chem. Abst. vol. 92 (1980), p. 196,061n.
Witkoski-Chem. Abst. vol. 97 (1982), p. 139,965q.

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