Tumor cells with increased immunogenicity and uses therefor

Details Tumor cells with increased immunogenicity and uses therefor Tumor cells with increased immunogenicity and uses therefor

1993-11-03

1999-01-12

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 4351723, 4353201, 435375, 435354, 435366, C12N 1509, C12N 510, C12N 1563

Patent

active

058587764

ABSTRACT:
Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic acid encoding a T cell costimulatory molecule, by using an agent which induces or increases expression of a T cell costimulatory molecule on the tumor cell surface or by coupling a T cell costimulatory molecule to the tumor cell surface. Tumor cells further modified to express MHC class I and/or class II molecules or in which expression of an MHC associated protein, the invariant chain, is inhibited are also disclosed. The modified tumor cells of the invention can be used in methods for treating a patient with a tumor, preventing or inhibiting metastatic spread of a tumor or preventing or inhibiting recurrence of a tumor. A method for specifically inducing a CD4.sup.+ T cell response against a tumor and a method for treating a tumor by modification of tumor cells in vivo are disclosed.

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