Tumor cell invasion-inhibiting peptides, peptide complexes and c

Details Tumor cell invasion-inhibiting peptides, peptide complexes and c Tumor cell invasion-inhibiting peptides, peptide complexes and c

1993-11-26

1996-08-20

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, 530329, 530345, A61K 3800, A61K 3804, C07K 500, C07K 700

Patent

active

055480624

ABSTRACT:
The present invention is a peptide having from 5 to 20 amino acid residues having tumor cell invasion-inhibiting activities. As such a peptide, a peptide represented by any one of the formulas (1) to (13) is preferred among peptides.
Further, the present invention is a cancer metastasis inhibitor comprising the above peptide as an active ingredient.
Furthermore, the present invention is a peptide complex having a peptide having tumor cell invasion-inhibiting activities and a polymer derived from a vital body chemically bonded to each other. As such a peptide, a peptide represented by any one of the formulas (1) to (14) is preferred among peptides. As the polymer derived from a vital body, a protein such as albumin or globulin is preferred.
Still further, the present invention is a cancer metastasis inhibitor comprising the above peptide complex as an active ingredient.

REFERENCES:
patent: 5082926 (1992-01-01), Chalberg et al.
patent: 5092885 (1992-03-01), Yamada et al.
patent: 5120828 (1992-06-01), Charonis
patent: 5175251 (1992-12-01), Johnson et al.
patent: 5190920 (1993-03-01), Eyal et al.
patent: 5231082 (1993-07-01), Schasteen
Isoai et al., Jpn. J. Cancer Res. Sep. 1990 (81) pp. 909-914.

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