Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-06-13
2006-06-13
Helms, Larry R. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S326000, C530S391700
Reexamination Certificate
active
07060802
ABSTRACT:
This invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention also provides methods for detecting TIP-2 antigen-bearing cancer cells in a sample, detecting the presence of TIP-2 antigen, optionally on the surface of cancer cells, immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells, diagnosing cancer in a subject, monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells, delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject, and treating cancer in a human subject. This invention further provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. This invention also provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ ID No:3) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ ID NO:4).
REFERENCES:
patent: 6197582 (2001-03-01), Trakht
patent: 6368826 (2002-04-01), Ligensa et al.
patent: 6455040 (2002-09-01), Wei et al.
patent: 1 006 184 (2000-06-01), None
patent: WO 91/09967 (1991-07-01), None
patent: 9947929 (1999-09-01), None
patent: WO 00/69898 (2000-11-01), None
De Vrise et al., PNAS 95:12340-45, 1998.
Westhof et al., Nature 311:123, 1984.
Greenspan et al., Nature Biotechnology 17:936-37, 1999.
Paul, Fundamental Immunology, Raven press, chapter 8, p. 242, 1993.
Rousset et al., Oncogene 16:643-54, 1998.
Green et al., Nature Genetics 7:13, 1994.
Campbell, Monoclonal antibody Technology, Elsevier Science Publishers, chapter 1, pp. 1-32, 1986.
Harlow et al., Antibodies, A laboratory manual, cold spring harbor laboratory, p. 322, 1988.
Campbell AM (1986) Monoclonal Antibody Technology. Elsevier Publishing Co., New York, pp. 1-32.
De Vries L, Lou X, Zhao G, Zheng B and Farquhar MG (1998) GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc. Natl. Acad. Sci. USA 95: 12340-12345.
Green LL, Hardy MC, Maynard-Currie CE, Tsuda, H, Louie DM et al. (1994) Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat. Genet. 7: 13-21.
Rousset R, Fabre S, Desbois C, Bantignies F and Jalinot P (1998) The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene 16:643-654.
Antonov AS, Nikolaeva MA, Klueva TS, Romanov YuA, Babaev VR, Bystrevskaya VB, Perov NA, Repin VS, Smirnov VN (1986) Primary culture of endothelial cells from atherosclerotic human aorta. Part 1. Identification, morphological and ultrastructural characteristics of two endothelial cell subpopulations. Atherosclerosis 59: 1-19.
Berman DM, Gilman AG (1998) Mammalian RGS proteins: barbarians at the gate. J Biol Chem 273: 1269-1272.
Borrebaeck CA, Danielsson L, Moller SA (1987) Human monoclonal antibodies produced from L-leucine methyl ester-treated and in vitro immunized peripheral blood lymphocytes. Biochem Biophys Res Commun 148: 941-946.
Brodin T, Olsson L, Sjogren HO (1983) Cloning of human hybridoma, myeloma and lymphoma cell lines using enriched human monocytes as feeder layer. J Immunol Methods 60: 1-7.
Casali P et al., (1986) Science 234: 476-479.
Galanos G et al. (1969) Eur J Biochem 9: 245-249.
Glassy MC, Handley HH, Hagiwara H, Royston I (1983) UC 729-6, a human lymphoblastoid B-cell line useful for generating antibody-secreting human—human hybridomas. Proc Natl Acad Sci (USA) 80: 6327-6331.
Goldman-Leikin RE, Salwen HR, Herst CV, Variakojis D, Bian ML et al. (1989) Characterization of a novel myeloma cell line, MM.1. J Lab Clin Med 113: 335-345.
Harlow E, Lane D (1988) Antibodies, A Laboratory Manual. Cold Spring Harbor Laboratory, pp. 319 and 322.
Kennedy MB (1995) Origin of PDZ (DHR, GLGF) domains. Trends Biochem Sci 20: 350.
Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495-497.
Kozbor D, Roder J (1981) Requirements for the establishment of high-titered human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus technique. J Immunol 127: 1275-1280.
Kozbor D, Tripputi P, Roder JC, Croce CM (1984) A human hybrid myeloma for production of human monoclonal antibodies. J. Immunol 133: 3001-3005.
Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T, Ishibasahi M (1997) Binding of high risk papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci (USA) 94: 11612-11616.
Lee SS, Weiss RS, Javier RT (1997) Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci (USA) 94: 6670-6675.
Levy R, Miller RA (1983) Tumor therapy with monoclonal antibodies. Fed Proc 42: 2650-2656.
Nilsson K, Ponten J (1975) Classification and biological nature of established human hematopoietic cell lines. Int J Cancer 15: 321-34.
Olsson L, Kronstrom H, Cambon-De Mouzon A, Honsik C, Brodin T, Jakobsen B (1983) Antibody producing human—human hybridomas. I. Technical aspects. J Immunol Methods 61: 17-32.
Östberg L, Pursch E (1983) Human X (mouse X human) hybridomas stably producing human antibodies. Hybridoma 2:361-367.
Posner MR, Schlossman SF, Lazarus H (1983) Novel approach to construction of human “myeloma analogues” for production of human monoclonal antibodies. Hybridoma 2:369-381.
Raison RL, Walker KZ, Halnan CR, Briscoe D, Basten A. (1982) Loss of secretion in mouse-human hybrids need not be due to the loss of a structural gene. J Exp Med 156: 1380-1389.
Reading CL (1982) Theory and methods for immunization in culture and monoclonal antibody production. J Immunol Methods 53: 261-291.
Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M (1995) Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci (USA) 92: 11810-11813.
Saras J, Heldin CH (1996) PDZ domains bind carboxy-terminal sequences of target proteins. Trends Biochem Sci 21: 455-458.
Scanlan MJ, Chen Y-T, Williamson B, Gure AO, Stockert, JD, Gordan O, Tureci O, Sahin U, Pfreundschuh M, Old LJ (1998) Characterization of human colon cancer antigens recognized by autologous antibodies. Int J Cancer 76: 652-658.
Scanlan MJ, Williamson B, Jungbluth A, Stockert E, Arden KC, Viars CS, Gure AO, Gordan JD, Chen Y-T, Old LJ (1999) Isoforms of the human PDZ-73 protein exhibit differential tissue expression. Biochim Biophys Acta 1445: 39-52.
Seabright S (1971) Lancet 2: 971-972.
Shenk T (1996) In: Fields Virology, (editors) Fields BN, Knipe DM, Howley PM (Lippinscott, Philadelphia), vol. 2, pp. 2111-2148.
Shnyra AA et al. (1990) In: Friedman H, Klein TW, Nakano M, Nowotny A, and Eds. Advances in Exp. Medicine & Biology Endotoxin New York: Plenum, 256: 681.
Teng NN, Lam KS, Calvo Riera F, Kaplan HS (1983) Construction and testing of mouse—human heteromyelomas for human monoclonal antibody production. Proc Natl Acad Sci. (USA) 80: 7308-7312.
Weiss MC, Green H (1967) Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proc Natl Acad Sci (USA) 58: 1104-1111; and.
Yunis JJ (1980) Cancer Genetics and Cytogenetics 2: 221-229.
U.S. patent application Ser. No. 09/917,974, Ligensa et al., filed Jul. 30, 2001.
U.S. patent application Ser. No. 10/013,056, Ligensa et al., filed Oct. 30, 2001.
Kirman I, Kalantarov GF, Lobel LI, Hibshoosh H, Estabrook A, Canfield R, Trakht I. (2002) Isolation of native human monoclonal nutoantibodies to breast cancer, Hybrid Hybridomics 21(6): 405-414.
Kalantarov GF, Rudchenko SA, Lobel L, Trakht I. (2002) Development of a fusion partner cell line for efficient production of human monoclonal antibodies from peripheral blood lymphocytes. Hum. Antibodies 11(3): 85-96.
Canfield Robert
Kalantarov Gary
Rudchenko Sergei
Trakht Ilya
Cooper & Dunham LLP
Helms Larry R.
The Trustees of Columbia University in the City of New York
White John P.
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