Tumor affinity peptide, and radioactive diagnostic agent and rad

Details Tumor affinity peptide, and radioactive diagnostic agent and rad Tumor affinity peptide, and radioactive diagnostic agent and rad

1995-06-05

1998-10-27

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 165, 530300, 530326, 530327, 530328, A61K 5100, A61M 3614

Patent

active

058274987

ABSTRACT:
A peptide having affinity with tumor or a salt thereof, which comprises an amino acid sequence containing 20 or less amino acid residues, said amino acid sequence being described as X.sub.1 -YCAREPPT-X.sub.2 wherein A, C, E, P, R, T and Y represent amino acid residues expressed by standard one-letter symbols, each of amino acid residues A, C, R and Y in the amino acid sequence YCAR may be in either L-form or D-form, X.sub.1 represents a basic organic compound having 1-3 amino groups, and X.sub.2 represents any given amino acid sequence, is provided together with a radioactive diagnostic agent and a radioactive therapeutic agent containing the above peptide or a salt thereof. The present tumor affinity peptide is high in radioactive metal labeling yield, useful for imaging and treating pathological tissues such as of breast cancer, ovarian cancer and colon cancer of mammals including human, and difficult to be readily metabolized in organisms and to accumulate in normal tissues especially at kidney and liver.

REFERENCES:
Synthetic Peptides Come of Age, The Journal of Nuclear Medicine, vol. 34, No. 11, pp. 15N, 18N, Nov. 1994.
Simona Ben-Haim et al., "The Safety and Pharmacokinetics in Adult Subjects of an Intravenously Administered .sup.99m Tc-labeled 17 Amino Acid Peptide (CYT-379)", Nucl. Med. Biol., vol. 21, pp. 131-142, 1994.
Irene Virgolini, M.D., et al., "Vasoactive Intestinal Peptide-Receptor Imaging for the Localization of Intestinal Adenocarcinomas and Endocrine Tumors", The New England Journal of Medicine, Oct. 27, pp. 1116-1121, 1994.
Nucl. Med. Biol., vol. 20, No. 4, 1993, pp. 443-452.

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