Tubulin promoter regulates gene expression in neurons

Details Tubulin promoter regulates gene expression in neurons Tubulin promoter regulates gene expression in neurons

1997-07-24

1999-12-14

Crouch, Deborah

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 435325, 435366, 435455, 536 241, C12Q 102

Patent

active

060007729

ABSTRACT:
The present invention relates to a DNA expression vector comprising a T.alpha.l .alpha.-tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.

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