Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-17
2007-07-17
Tucker, Zachary C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S295000
Reexamination Certificate
active
11451078
ABSTRACT:
The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making hemifumarate compounds and compositioning of the present invention.
REFERENCES:
patent: 2003/0092718 (2003-05-01), Haap et al.
patent: 2005/0075357 (2005-04-01), Zhang et al.
patent: WO 02/074753 (2002-09-01), None
patent: WO 2005/030216 (2005-04-01), None
patent: WO 2005/030775 (2005-04-01), None
S. Kushner, et al., J. Amer. Chem. Soc., vol. 74, pp. 3617-3621, 1952.
Eric K. Rowinsky and Anthony W. Tolcher, Cancer Principles & Practice of Oncology, 6thEdition, pp. 431-452, 2001.
Michael M. Gottesman, Annu. Rev. Med., vol. 53, pp. 615-627, 2002.
Afragola Jay Thomas
Blum David Michael
Doyle Timothy John
Schmid Jean
Wu Yanzhong
Leeser Erich A.
Moran Daniel B.
Tucker Zachary C.
Wyeth
LandOfFree
Tubulin inhibitor and process for its preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tubulin inhibitor and process for its preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tubulin inhibitor and process for its preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3763835