Tuberculosis vaccines including recombinant BCG strains...

Details Tuberculosis vaccines including recombinant BCG strains... Tuberculosis vaccines including recombinant BCG strains...

2003-04-16

2009-11-03

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C536S023100, C536S023700, C530S300000, C530S350000, C424S009100, C424S009200, C424S185100, C424S190100, C424S243100, C435S007100, C435S007200

Reexamination Certificate

active

07611720

ABSTRACT:
The invention relates to a live recombinantMycobacterium bovis-BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that exhibits alanine dehydrogenase activity, glutamine synthetase activity, or serine dehydratase activity.

REFERENCES:
patent: WO 00/11214 (2000-03-01), None
patent: WO 01/078774 (2001-10-01), None
TB Vaccines: Progress and Problems; Trends in Immunology, vol. 22, Issue 3, dated Mar. 1, 2001, pp. 160-168.
Long-Term Maintenance Bacille Calmette-Guerin Therapy in High-Grade Superficial Bladder Cancer; Urology, vol. 59, Issue 3, dated Mar. 2002, pp. 414-418.
Glutamine Synthetase ofMycobacterium tuberculosis: Extracellular Release and Characterization of its Enzymatic Activity; Proc. Natl. Acad. Sci. USA, vol. 91, dated Sep. 1994, pp. 9342-9346.
An Inhibitor of ExportedMycobacterium tuberculosisGlutamine Synthetase Selectively Blocks the Growth of Pathogenic Mycobacteria in Axenic Culture and in Human Monocytes: Extracellular Proteins as Potential Novel Drug Targets; Department of Medicine, University of California at Los Angeles School of Medicine, vol. 189, No. 9, dated May 3, 1999, pp. 1425-1435.
Mycobacterium bovisBCG Vaccines Exhibit Defects in Alanine and Serine Catabolism; Infection and Immunity, Feb. 2003, pp. 708-716.

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