Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1988-08-16
1992-04-28
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, 4351721, A61K 3902, C12N 1500
Patent
active
051087456
ABSTRACT:
Vaccines and methods for their use in producing effective immune responses in mammalian hosts subsequently exposed to infection by intracellular pathogens including Legionella pneumophila wherein extracellular products of the pathogens are used as vaccines. After selecting a target intracellular pathogen, extracellular products of the selected pathogen which stimulate strong lymphocyte proliferative responses in immune hosts are then utilized as vaccines to immunize subsequent mammalian hosts to the target intracellular pathogen.
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Conlan et al., Journal of General Microbiology, vol. 134, pp. 481-487, 1988.
"Purification and Characterization of an Extracellular Protease of Legionella pneumophila", Lawrence A. Dreyfus and Barbara H. Iglewski, Infection and Immunity, Mar. 1986, pp. 736-743.
"In Vitro Production of an Extracellular Protease by Legionella pneumophila", Michael R. Thompson, Richard D. Miller and Barbara H. Iglewski; Infection and Immunity, Oct. 1981, pp. 299-302.
"Interferon-.gamma.-Activated Human Monocytes Inhibit the Intracellular Multiplication of Legionella pneumophila", Nina Bhardwaj, Thomas W. Nash and Marcus A. Horwitz, The Journal of Immunology, vol. 137, pp. 2662-2669, No. 8, Oct. 15, 1986.
"Interaction between the Legionnaires' Disease Bacterium (Legionella pneumophila) and Human Alveolar Macrophages", Thomas W. Nash, Daniel M. Libby and Marcus A. Horwitz; The American Society for Clinical Investigation, vol. 74, Sep. 1984, pp. 771-782.
"Activated Human Monocytes Inhibit The Intracellular Multiplication of Legionnaires' Disease Bacteria", Marcus A. Horwitz and Samuel C. Silverstein, J. Exp. Med., vol. 154, Nov. 1981, pp. 1618-1635.
"Enzymatic Activities of Legionella pneumophila and Legionella-like Organisms", Frederick S. Nolte, Gary E. Hollick and Richard G. Robertson, Journal of Clinical Microbiology, Jan. 1982, pp. 175-177.
Brown Johnnie R.
Mohamed Abdel A.
The Regents of the University of California
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