Tuberculine active peptides and a process for preparing same by

Details Tuberculine active peptides and a process for preparing same by Tuberculine active peptides and a process for preparing same by

1983-03-15

1984-07-17

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044605030

ABSTRACT:
The octapeptide Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly and the hexadecapeptide Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-Lys-Asn-Gly-Ser-Gln-Met-Arg-Leu, part of a tuberculin-active intracellular myobacterial protein, have been synthesized. The synthetic peptides were shown to possess tuberculin activity by their ability to induce a delayed-type allergic reaction in skin tests on Mycobacterium tuberculosis sensitized guinea pigs.

REFERENCES:
patent: 3812091 (1974-05-01), Ondetti
patent: 3888837 (1975-06-01), Tsumita et al.
patent: 3943119 (1976-03-01), Tsumita et al.
patent: 4290944 (1981-09-01), Goldberg
patent: 4374765 (1983-02-01), McGregor
patent: 4376760 (1983-03-01), Jung et al.
patent: 4390528 (1983-06-01), Najjar
patent: 4395404 (1983-07-01), Low et al.

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