TTTr as protective group in nucleotide synthesis

Details TTTr as protective group in nucleotide synthesis TTTr as protective group in nucleotide synthesis

1994-09-12

1997-06-17

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2531, 536 2533, 536 2534, 536 267, 536 2671, 536 2672, 536 2674, 536 268, 536 2711, 536 276, 536 281, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 100

Patent

active

056398670

ABSTRACT:
The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4"-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a process for the preparation of oligonucleotides, and to the use of said protected nucleosides, nucleotides and oligonucleotides.

REFERENCES:
patent: 5268464 (1993-12-01), Brill
S.L. Beaucage et al., Tetrahedron, 48, pp. 2223-2311 (1992).
Gibson, H.W., et al., J. Org. Chem. 58, pp. 3748-3756 (1993).
Takenaka, S. et al. Analytical Sciences Feb. 1992 vol. 8 pp. 3-7.
Townsend, L., Chemistry of Nucleosides and Nucleotides, vol. 1 (1988) pp. 283-367 Chapter 3.
Gait, M.J. et al Chemical and Enzymatic Synthesis of Gene Fragments, Verlag Chemie, Weinheim, 1-42 (1982).
Ashton, P. et al, J. Chem. Soc., Chem. Commun. pp. 1124-1128 (1992).
Marvel, C.S. et al. J. Am. Chem. Soc. 63:1892-1896 (1941) vol. 63.

Affiliated with

Also associated with

Rating

TTTr as protective group in nucleotide synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TTTr as protective group in nucleotide synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TTTr as protective group in nucleotide synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2158800