Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-07-03
2007-07-03
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S183000, C435S091500, C435S094000, C530S350000, C536S023100, C536S023500
Reexamination Certificate
active
10049586
ABSTRACT:
The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA molecule encoding TNF-α, and methods of inhibiting the degradation of an mRNA molecule encoding GM-CSF. Also provided are methods for identifying compounds that regulate the destruction of mRNA molecules containing AREs.
REFERENCES:
patent: 6627398 (2003-09-01), Wilusz et al.
patent: WO 97/42820 (1997-11-01), None
patent: WO 97/42820 (1997-11-01), None
Akashi et al. Role of AUUUA sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells.Blood78:2005-2012 (1991).
Barnard et al.Nucl. Acids Res.21:3580 (1993).
Beelman et al. Degradation of mRNA in eukaryotes.Cell81:179 (1995).
Bohjanen et al. AU RNA-binding factors differ in their binding specificities and affinities.J. Biol. Chem.267:6302-6309 (1992).
Bohjanen et al. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA.Mol. Cell. Biol.11:3288-3295.
Caput et al. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators.Proc. Natl. Acad. Sci. USA83:1670-1674 (1986).
Carballo et al. Bone marrow transplantation reproduces the tristetrapolin-deficiency syndrome in recombination activating gene-2(-/-) mice.J. Clin. Invest.100(5):986-995 (1997).
Carballo et al. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.Blood95(6):1891-1899 (Mar. 15, 2000).
Carballo et al. Tristetraprolin is a regulator of granulocyte-macrophage colony-stimulating factor mRNA stability.Exper. Hematol.28(No. 7 Suppl. 1):36 (Jul. 2000).
Carballo et al. Feedback inhibition of macrophage tumor necrosis factor-alpha (TNFα) production by tristetraprolin (TTP),Science281(5379):1001-1005 (Aug. 14, 1998).
Chen et al. AU-rich elements: characterization and importance in mRNA degradation.Trends Biochem. Sci.20:465-470 (1995).
Chen et al. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation.Mol. Cell. Biol.15:5777 (1995).
Chen et al. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.Mol. Cell. Biol.14:8471 (1994).
De et al. Identification of four CCCH zinc finger proteins inXenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression.Gene228(1-2):133-145 (Mar. 4, 1999).
DuBois et al. Growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.J. Biol. Chem.265(31):19185-19191 (1990).
Han et al. Interactive effects of the tumor necrosis factor promoter and 3′ untranslated regions.J. Immunol.146:1843 (1991).
Kim et al. Binding of a protein to an AU-rich domain of tumor necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes.Biochem. J.316:455-460 (1996).
Lai et al. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprotin-related zinc finger proteins to Au-rich elements and destabilization of mRNA.J. Biol. Chem.275(23):17827:17837 (Jun. 9, 2000).
Lai et al. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.Mol. Cell. Biol.19(6):4311-4323 (Jun. 1999).
Ma et al. The yeast homologue YTIS11, of the mammalian TIS11 gene family is a non-essential, glucose repressible gene.Oncogene10:487-494 (1995).
Muller et al. Association of AUUUA-binding protein with A+U-rich mRNA during nucleo-cytoplasmic transport.J. Mol. Biol.226:721-733 (1992).
Nie et al. ERF-2, the human homologue of the murine Tis11d early response gene.Gene152:285-286 (1995).
Peng et al. Functional characterization of a non-AUUUA AU-rich element from thec-junproto-oncogene mRNA: Evidence for a novel class of AU-rich elements.Mol. Cell. Biol.16(4):1490-1499 (1996).
Rubin et al. A poly (A) binding protein-specific sequence motif: MRTENGKSKGFGFVC binding to mRNA poly (A) and polynucleotides and its role on mRNA translation.Biochem. Mol. Biol. Int.33:575 (1994).
Sachs. Messenger RNA degradation in eukaryotes.Cell74:413 (1993).
Shaw et al. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation.Cell46:659-667 (1986).
Stevens et al. Blastomeres and cells with mesendodermal fates of carp embryos express cth1, a member of the TIS11 family of primary response genes.Int. J. Dev. Biol.42:181-188 (1998).
Stoecklin et al. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.J. Biol. Chem.269(18):28591-28597 (1994).
Taylor et al. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes.Nucl. Acids Res.19(12):3454 (1991).
Thompson et al. Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.Gene174(2):225-233 (1996).
Varnum et al. The TIS11 primary response gene is a member of a gene family that encodes with a highly conserved sequence containing an unusual Cys-His repeat.Mol. Cell. Biol.11:1754-1758 (1991).
Wang et al. Posttranscriptional regulation of protein expression in human carcinoma cells by adenine-uridine-rich elements in the 3′-untranslated region of tumor necrosis factor-alpha messenger RNA.Cancer Res.57:5426-5433 (1997).
Xu et al. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay.Mol. Cell. Biol.17(8):4611-4621 (1997).
Abraham et al., “p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group,” JAMA. May 21, 1997;277(19):1531-8.
Achsel and Shimura, “Factors involved in the activation of pre-mRNA splicing from downstream splicing enhancers,” J Biochem (Tokyo). Jul. 1996;120(1):53-60.
Agui et al., Stimulation of interleukin-6 production by endothelin in rat bone marrow-derived stromal cells. Blood 84:2531, 1994.
Antman et al.,: Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N. Engl. J. Med. 319:593, 1988.
Baker EJ, Liggit P: Accelerated poly(A) loss and mRNA stabilization are independent effects of protein synthesis inhibition on alpha-tubulin mRNA in Chlamydomonas. Nuc. Acids. Res. 21:2237, 1993.
Beelman and Parker: Degradation of mRNA in eukaryotes. Cell 81:179, 1995.
Beelman and, Parker: Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J. Biol. Chem. 269:9687, 1994.
Bentley, SA: The role and composition of the adherent layer in long-term bone marrow culture. In: Long term bone marrow culture: proceedings of a symposium held at the Kroc Foundation. Kroc Foundation Series, vol. 18. Alan R. Liss, Inc. New York. 1984.
Beutler “TNF, immunity and inflammatory disease: lessons of the past decade.” J Investig Med. Jun. 1995;43(3):227-35.
Beutler B. and T. Brown, “A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.” J Clin Invest. Apr. 1991;87(4):1336-44.
Blackshear, P.J. 1984. Systems for polyacrylamide gel electrophoresis. Methods Enzymol. 104:237-255.
Carballo et al., Phagocytic and macropinocytic activity in MARCKS-deficient macrophages and fibroblasts. Am. J. Physiol. 277:163, 1999.
Cheng et al. “Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.” Genes Dev. Aug. 1992;6(8):1444-56.
Blackshear Perry J.
Carballo-Jane Ester
Lai Wi S.
Needle & Rosenberg P.C.
Sisson Bradley L.
The United States of America as represented by the Secretary of
LandOfFree
TTP-related zinc finger domains and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with TTP-related zinc finger domains and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TTP-related zinc finger domains and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3780986