Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1997-09-04
1998-12-22
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435 6, 4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104
Patent
active
058518096
ABSTRACT:
The invention provides Tryptophanyl tRNA Synthetase polypeptides and DNA (RNA) encoding Tryptophanyl tRNA Synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Tryptophanyl tRNA Synthetase polypeptides to screen for antibacterial compounds.
REFERENCES:
Lindler, et al., Molecular Cloning and Characterization of a Streptococcus Sanquis Dnase Necessary for Repair of DNA Damage Induced by UV Light and Methyl Methanesulfonate. Journal of Bacteriology. Jul. 1987, vol. 169: No. 7, pp. 3199-3208, see entire document.
Brakhage, et al., Structure and Nucleotide Sequence of the Bacillus Subtilis Phenylalanyl-tRNA Synthetase Genes. Biochimie. 1990, vol. 72: pp. 725-734, see entire document.
Putzer, et al., Independent Genes for Two Threonyl-tRNA Synthetases in Bacillus Subtilis. Journal of Bacteriology. Aug. 1990, vol. 172: No. 8, pp. 4593-4602, see entire document.
Springer, et al., Genetic Definition of the Translational Operator of the Threonine-t-RNA Ligase Gene in Escherichia Coli. Proc. Natl. Acad. Sci. USA. Jun. 1986, vol. 83: pp. 4384-4388, see entire document.
Gimmi Edward R.
Hobbs Lisa J.
King William T.
Prouty Rebecca E.
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