Tryptophan derivatives as protein tyrosine kinase blockers and t

Details Tryptophan derivatives as protein tyrosine kinase blockers and t Tryptophan derivatives as protein tyrosine kinase blockers and t

1994-04-28

1998-07-07

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548496, 514339, 514421, 5462774, C07D40102, C07D20910, A61K 3147, A61K 31405

Patent

active

057769702

ABSTRACT:
Tryptophan derivatives substituted by a hydrophobic group, e.g. carbobenzoxy, at the N-terminus, and a hydrophilic group, e.g. --COOH, --SO.sub.3 H or --PO.sub.3 H, at the C-terminus, were found to be cell-permeable blockers of protein tyrosine kinases (PTKs). These PTK blockers are useful in basic research and in the treatment of neoplastic diseases.

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